Impact of BNT162b2 mRNA anti-SARS-CoV-2 vaccine on interferon-alpha production by plasmacytoid dendritic cells and autoreactive T cells in patients with systemic lupus erythematosus: The COVALUS projectArticle Published on 2023-01-012023-07-11 Journal: Journal of autoimmunity [Category] COVID19(2023년), [키워드] mRNA vaccine. plasmacytoid dendritic cells SARS-CoV-2 systemic lupus erythematosus Type-1 interferon [DOI] 10.1016/j.jaut.2022.102987 PMC 바로가기
The relation of the frequency and functional molecules expression on plasmacytoid dendritic cells to postpartum hepatitis in women with HBeAg-positive chronic hepatitis B virus infectionArticle Published on 2022-11-092023-06-12 Journal: Frontiers in Immunology [Category] B형 간염, Fulltext, [키워드] Antiviral treatment Chronic Hepatitis B Immunity plasmacytoid dendritic cells postpartum. [DOI] 10.3389/fimmu.2022.1062123 PMC 바로가기
Plasmacytoid dendritic cells during COVID-19: Ally or adversary?COVID-19 동안 형질세포양 수지상 세포: 동맹 또는 적Review Published on 2022-07-262022-09-11 Journal: Cell Reports [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 airways Alpha Antiviral antiviral responses antivirals causative agent Cell cellular contribute coronavirus COVID-19 COVID-19 disease CP: Immunology CP: Microbiology dendritic cell dendritic cells detrimental effect detrimental effects disease IFN IFNs IFNα immune system immunology infections Inflammation Interferon alpha Microbiology outcome pDC pDCs plasmacytoid dendritic cells plasmacytoid dendritic cells. SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus subset sustained thought type I interferon viral infection viral infections virus [DOI] 10.1016/j.celrep.2022.111148 PMC 바로가기 [Article Type] Review
Toll-like receptors matter: plasmacytoid dendritic cells in COVID-19Toll-like 수용체의 중요성: COVID-19의 형질세포양 수지상 세포Article Published on 2022-05-162022-09-11 Journal: The EMBO Journal [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Analysis Antiviral COVID-19 COVID-19 patients cytokine response dendritic cell dendritic cells disease severity IFN-I induce infections journal mechanisms molecular mechanism molecular mechanisms plasmacytoid dendritic cell plasmacytoid dendritic cells progenitor cell question reduced response Serum level Toll-like receptor type I interferon unique virus [DOI] 10.15252/embj.2022111208 PMC 바로가기 [Article Type] Article
Do reduced numbers of plasmacytoid dendritic cells contribute to the aggressive clinical course of COVID-19 in chronic lymphocytic leukaemia?감소된 수의 형질세포양 수지상 세포가 만성 림프구성 백혈병에서 COVID-19의 공격적인 임상 경과에 기여합니까?Review Published on 2022-04-012022-09-11 Journal: Scandinavian journal of immunology [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] agammaglobulinemia BTK Chronic lymphocytic leukaemia Clinical course CLL combating contribute COVID-19 dendritic cells Express haematological malignancies inhibitor interferon interferons IRF7 malignancies mechanism observations patients patients with haematological pDC pDCs plasmacytoid dendritic cell plasmacytoid dendritic cells reduced reduction in SARS-CoV-2 TLR7 Toll-like receptor toll-like receptor 7 toll-like receptor 7. type I interferons tyrosine X-linked X-linked agammaglobulinemia [DOI] 10.1111/sji.13153 PMC 바로가기 [Article Type] Review
Myeloid cell interferon responses correlate with clearance of SARS-CoV-2골수 세포 인터페론 반응은 SARS-CoV-2 제거와 관련이 있습니다Article Published on 2022-02-032022-09-10 Journal: Nature Communications [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료제, [키워드] accumulation ACE2 angiotensin angiotensin-converting enzyme 2 Anti-viral appearance BAL baseline Bronchoalveolar lavage CD163 CD68 Cell cell suspension changes in clearance of SARS-CoV-2 correlated COVID-19 patients COVID-19-related death dendritic cells emergence exhibiting expressing expression gene signature heterogeneous HLADR host response host responses Human immune Immune cell immune profiling immunopathology increased risk individual cells infected with SARS-CoV-2 Infection Inflammation Inflammatory Innate immunity interferon interferon response lung Lungs macaque macaques Macrophage macrophages Mutant SARS-CoV-2 myeloid observé plasmacytoid dendritic cell plasmacytoid dendritic cells Population reported response rhesus macaque rhesus macaques RNAseq SARS-CoV-2 SARS-COV-2 infection scRNAseq SIGLEC1 significantly Single Cell strain T-lymphocyte T-lymphocytes transcriptional transcriptional change Transcriptional changes Type type I interferon type I interferon response Viral viral clearance viral dynamics viral infection Viremia while [DOI] 10.1038/s41467-022-28315-7 PMC 바로가기 [Article Type] Article
Human genetic and immunological determinants of critical COVID-19 pneumoniaReview Published on 2022-01-282022-10-05 Journal: Nature [Category] 변종, 유전자 메커니즘, 진단, [키워드] age and gender age and sex auto-antibody autosomal cellular childhood COVID-19 Critical deficiencies determinant explained FIVE Genetic greater Host Human IFNs IFNα IFNβ Immunity immunological Inborn error individual Infection men molecular Neutralizing older patients Patient plasmacytoid dendritic cells Pneumonia proportion respiratory epithelial cell respiratory tract risk of death SARS-CoV-2 SARS-COV-2 infection Spread systemic inflammation TLR3 TLR7 Trigger Type I IFN type I interferon virus women younger patients [DOI] 10.1038/s41586-022-04447-0 [Article Type] Review
What’s happening where when SARS-CoV-2 infects: are TLR7 and MAFB sufficient to explain patient vulnerability?Review Published on 2022-01-222022-10-30 Journal: Immunity & Ageing : I & A [Category] COVID-19, [키워드] age Characteristics COVID-19 COVID-19 pandemic cytokine response demographic group dendritic cell explain Infection interferon Macrophage macrophages MAFB Male sex miR-146a obese obesity pathway Patient patient groups plasmacytoid dendritic cells pro-inflammatory cytokine SARS-CoV-2 sensitivity severe COVID-19 disease Severe infection skewed TLR-tolerance TLR7 vulnerable patients [DOI] 10.1186/s12979-022-00262-3 PMC 바로가기 [Article Type] Review
Why Females Do Better: The X Chromosomal TLR7 Gene-Dose Effect in COVID-19여성이 더 잘하는 이유: 코로나19에서 X 염색체 TLR7 유전자 용량 효과Immunology Published on 2021-11-112022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 치료법, [키워드] age biallelic caused concerning contribute COVID-19 COVID-19 pandemic COVID-19 treatment dendritic cells Effect expression Factor female gene-dose effect Hypothesis ICU IFN IFN pathway IFN response Immune cell immune cells Immunopathogenesis inactivation Infection interferon investigated Male sex modulation Mortality Pattern recognition pattern recognition receptor Pattern recognition receptors plasmacytoid dendritic cell plasmacytoid dendritic cells Protective responsible SARS-CoV-2 severe COVID-19 severity Sex difference sex differences sex hormone Sex hormones ssRNA TLR TLR7 TLR7 gene Toll-like receptor Treatment type 1 interferon Viral viral infections X chromosome X chromosome inactivation escape [DOI] 10.3389/fimmu.2021.756262 PMC 바로가기 [Article Type] Immunology
Predictors of neutralizing antibody response to BNT162b2 vaccination in allogeneic hematopoietic stem cell transplant recipientsResearch Published on 2021-10-242022-10-29 Journal: Journal of Hematology & Oncology [Category] COVID-19, [키워드] administration Adults affecting Allogeneic analysis anti-RBD binding antibody binding domain BNT162b2 BNT162b2 mRNA vaccine CD4 Cell chronic chronic GVHD comparable correlated COVID-19 Cytometry cytometry analysis detectable Factor first vaccination Flow follicular GVHD healthy help helper T cell Hematopoietic cell transplantation identify immunization indicated marker memory B cell mRNA vaccination mRNA vaccine multivariate analyses Neutralizing Neutralizing antibody response Patient patients peripheral blood cell plasmacytoid dendritic cells postvaccination predictor RBD recipient reduced Registered response responses Result risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptor significantly lower Stem cell transplantation supplementary material Switched B cells T cell T-SNE therapy vaccination Vaccine was performed were assessed wild type [DOI] 10.1186/s13045-021-01190-3 PMC 바로가기 [Article Type] Research